So I recently finished the first season of Walking Dead and like many other shows, movies, and video games it made me think that it would be a cool setting for a world. In my current campaign one of the many worlds was a mix between the films Hero, Spirited Away and the show Avatar: The Last Air Bender. Another world was strongly inspired by the Metroid Prime games.
There's so many to choose from I'm going to have to think about it for a while, but I wanted to put the question out there just so we have something cool to talk about this weekend in the forums. I know some already exist, Star Wars, Star Trek, Serenity, etc. But if you could turn something into a setting that hasn't been done yet what would it be? Why?